Buried in a dormant life and a dead end relationship, Dr. Jason Frankenstein, the last of his family, finds himself frustratingly approaching the middle of his life with little progress to show towards carrying forward his family's experiment. But after a creature from his past brutally re-enters his life, he is catalyzed to finally complete his work. With the help of a pair of drug dealing paramedics and a nurse with a shady past, he sets down the blood-soaked path to create a living being from the bodies of the dead.